HER-2/neu基因检测试剂盒
| 型 号： | 广州创仑 |
| 报 价： |  |
本HER-2/neu基因检测试剂盒 荧光原位杂交法检测乳腺癌细胞中HER-2/neu基因（17q12）的扩增，现已证实，HRE-2的过度表达可潜在激活EGFR的信号通路，同时可促进EGFR介导的转化和肿瘤的发生。
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HER-2/neu基因检测试剂盒
广州健仑生物科技有限公司
我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。
C-erbB-2和Her-2人类基因是因其与逆转录病毒V—erbB-2相似而被发现。之后Coussens L及Schechte AL等对Neu，Her-2，C-erbB-2进行测序及染色体定位分析，证明他们是同一基因。
人类该基因定位于染色体17q12，其编码产物为185kD的跨膜精蛋白p185，由1255个氨基酸组成，720—987位属于酪氨酸激酶区。Her-2/neu蛋白是具有酪氨酸蛋白激酶活性跨膜糖蛋白，是EGFR家族成员之一。
Her-2/neu蛋白由胞外的配体结合区、单链跨膜区及胞内的蛋白酪氨酸激酶区三部分组成，由于目前尚未发现能与Her-2/neu蛋白直接结合的配体．其主要通过与家族中其他成员包括EGFR(HERl/erbBI)，HER3/erbB3。HER4/erbB4形成异二聚体而与各自的配体结合。Her-2/neu蛋白常为异二聚体*伴侣，且活性常强于其它异二聚体。当与配体结合后，主要通过引起受体二聚化及胞浆内酪氨酸激酶区的自身磷酸化．激活酪氨酸激酶的活性。
现已证实，HRE-2的过度表达可潜在激活EGFR的信号通路，同时可促进EGFR介导的转化和肿瘤的发生。HER-2/neu基因检测试剂盒
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以下是我司出售的部分FISH产品：
| GLI1（12q13）基因探针 |
| 5q探针 |
| 7q探针 |
| 20q荧光原位杂交探针 |
| EVI1（3q26）基因断裂探针 |
| AML1/ETO融合基因t(8;21)探针 |
| AML/ETO融合基因检测试剂盒（荧光原位杂交法） |
| PML/RARA融合基因t(15;17)探针 |
| PML/RARA融合基因检测试剂盒（荧光原位杂交法） |
| KMT2A(MLL)(11q23)基因断裂探针 |
| CBFB(16q22)基因断裂探针 |
| RARA(17q21)基因断裂探针 |
| AML1（21q22）基因断裂探针 |
| ETV6/AML1融合基因 t(12;21) 探针 |
| ETV6(12p13)基因断裂探针 |
| CDKN2A（9p21）基因探针（红色） |
| E2A（19p13）基因断裂探针 |
| 4、10、17染色体计数探针 |
| MYC（8q24）基因断裂探针 |
| CCND1(BCL1)/IGH融合基因t(11;14)探针 |
| MAF/IGH融合基因t(14;16)探针 |
| FGFR3/IGH融合基因t(4;14)探针 |
| MAFB/IGH融合基因t(14;20)探针 |
| 11q23及DLEU1基因探针 |
| 15q22及6q21基因探针 |
| 1q21和1p36基因探针 |
| IGH（14q32）基因断裂探针 |
| MYC/IGH融合基因t(14;8)探针 |
| MYEOV/IGH融合基因t(11;14)探针 |
| BCL2/IGH融合基因t(14;18)探针 |
| MALT1（18q21）基因断裂探针 |
| CCND1（11q13）基因断裂探针 |
| BCL6（3q37）基因断裂探针 |
我司还提供：登革热，黄热病，基肯孔热，西尼罗河，立次克体，无形体，蜱虫，恙虫，锥虫，利什曼原虫，RK39, 汉坦病毒，乙脑，森林脑炎，寨卡病毒 ，H7N9 ,流感，霍乱，军团菌，结核，诺如病毒，轮状病毒，炭疽，O157，葡萄球菌 ，流行性出血热，伤寒杆菌，志贺氏菌检测试剂,！
The human genes of C-erbB-2 and Her-2 are discovered because they are similar to retrovirus V - erbB-2. After Coussens L and Schechte AL, Neu, Her-2, C-erbB-2 were sequenced and chromosomal location analysis proved that they were the same gene.
The human gene is located on chromosome 17q12, and its encoded product is 185kD transmembrane protamine p185, which is composed of 1255 amino acids. The 720 to 987 belongs to the tyrosine kinase region. Her-2/neu protein is a tyrosine protein kinase active transmembrane glycoprotein and is one of the members of the EGFR family.
Her-2/neu protein by extracellular ligand binding region, a single transmembrane region and intracellular protein tyrosine kinase domain is composed of three parts, because has not yet found the ligand can bind directly to Her-2/neu protein. It mainly through other members with family including EGFR (HERl/erbBI), HER3/ erbB3. HER4/erbB4 forms an isooligomer and combines with the respective ligands. The Her-2/neu protein is often the preferred mate of the isomer, and the activity is often stronger than the other iso - two - polymer. When binding to the ligand, the activity of tyrosine kinase is activated mainly by causing the receptor dimerization and the autophosphorylation of the tyrosine kinase region in the cytoplasm.
It has been shown that overexpression of HRE-2 can potentially activate EGFR signaling pathways, and also promote EGFR mediated transformation and tumor formation.
