落基山斑疹伤寒立克次体IgM ELISA试剂盒

Rickettsia rickettsii IgM ELISA Kit

广州健仑生物科技有限公司

主要用途：用于检测人血清中的落基山斑疹伤寒立克次体IgM抗体

产品规格：96人份/盒

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落基山斑疹伤寒立克次体IgM ELISA试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

形成一个功能性动力蛋白-2马达需要这两个基因编码的蛋白质，这就解释了为什么任一个基因发生突变都会引发ciliopathy。这项工作还确定了动力蛋白-2的新组分(TCTEX1D2)，提供一个候选基因，其突变或可导致年轻综合征。
日本理化学研究所(RIKEN)脑科学研究所的研究人员，联合顺天堂大学和日本科学技术振兴机构，发现一种广泛参与细胞内钙信号转导的细胞受体——IP3受体——可通过酶的作用被锁定在闭合状态中，且该锁定作用可能在神经变性中出现的神经信号减少中发挥作用，如亨廷顿氏和阿尔茨海默氏病。
在发表于当前的《PNAS》杂志上的研究中，科学家报道了，在人类细胞和亨廷顿氏病的小鼠模型的实验中，揭示2型转谷氨酰胺酶——一种在神经变性疾病患者中的细胞升高的蛋白交联酶——与IP3受体相互作用，将其锁定在在一个封闭的非功能性结构中，阻止其履行必要的钙释放作用。他们确定了该受体上的一个特定的氨基酸位点，Gln2746，其可以进行修饰作用，这项研究加深了我们对于受体如何被锁定的理解，以及可能打开了通过构象变化来研究其他功能蛋白的大门。
IP3受体通道位于内质网上，在细胞内钙信号传导中发挥至关重要作用，并参与多种细胞功能，包括线粒体能量产生和自噬调节。虽然自噬通常情况下是维持细胞维修的一个机制，但它也可以触发细胞功能的丧失，并明显与一些神经变性疾病有关，包括亨廷顿氏病，阿尔茨海默氏病和帕金森氏病有关。

The formation of a functional dynein-2 motor requires proteins encoded by both genes, which explains why mutations in either gene can trigger ciliopathy. This work also identified a new component of dynein-2 (TCTEX1D2), which provides a candidate gene whose mutation may lead to young syndrome.
Researchers at the RIKEN Institute for Brain Science, in collaboration with Sun Yat-Sen University and Japan's Agency for the Advancement of Science and Technology, have found that a cellular receptor widely involved in intracellular calcium signaling, the IP3 receptor, The action of the enzyme is locked in a closed state and this locking effect may play a role in the reduction of neural signals that occur in neurodegeneration such as Huntington's and Alzheimer's disease.
In a study published in the current issue of PNAS, scientists reported that experiments in mouse models of human cells and Huntington's disease revealed that type 2 transglutaminase, a protein found in patients with neurodegenerative diseases The cell-augmented protein-linked enzyme, which interacts with the IP3 receptor, locks it in a closed, non-functional structure that prevents it from performing the necessary calcium release. They identified a specific amino acid site on the receptor, Gln2746, which can be modified, deepening our understanding of how receptors are locked and possibly opening up the possibility of studying other functional proteins through conformational changes The door.
The IP3 receptor channel, located in the endoplasmic reticulum, plays a crucial role in intracellular calcium signaling and is involved in a variety of cellular functions including mitochondrial energy production and autophagy regulation. Although autophagy is usually a mechanism for maintaining cell maintenance, it can also trigger the loss of cellular function and is clearly associated with several neurodegenerative diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease .