康氏立克次氏体IgG免疫荧光试剂盒

Rickettsia conorii IgG IFA Kit

广州健仑生物科技有限公司

主要用途：用于检测人血清中的康氏立克次氏体IgG抗体

产品规格：12 孔/张,10 张/盒

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康氏立克次氏体IgG免疫荧光试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

在这项工作中，科学家提出了一个通用的模型发现，由2型转谷氨酰胺酶的作用造成异常的IP3受体介导的钙信号转导，导致细胞功能紊乱，随后出现大脑功能障碍。转谷氨酰胺酶2的激活通常与炎症和应激有关，以及IP3通道上的转谷氨酰胺酶2作用，可能会为常见于不同的神经变性疾病的发生和发展步骤提供一个证据。
这项研究的*Katsuhiko Mikoshiba说：“我们认为，我们在这项研究中所确定的机制，可以为我们提供一个研究大脑和身体的其他部位的其他疾病的通用模型，其中2型转谷氨酰胺酶被上调。我们希望这种认知zui终可能为许多神经退行性疾病开发新的药物疗法，这些疾病为患者和社会带来沉重的负担。”
大约50年前，电子显微镜揭示了细胞内形成的类似斑点的结构，它们到处移动然后消失。但科学家们并不知道它们存在的意义——据称这些移动的类似云的蛋白质集合对细胞生命至关重要，因此它们或可能提供疾病治疗的新方法。
在期刊《细胞生物学》上发表在一项研究里，两名研究人员呼吁不同背景的科研者，从生物学到细胞生物学，将关注点集中在这些构造的用途上，他们启用了一个统一的术语“集合体”来指代它们。
“我想要了解尤文肉瘤里的这些集合体在做什么，尤文肉瘤是我正在关注研究的疾病，我认为所有研究人体生物学的其他科研人员应该也会想要知道集合体在健康人群和疾病人群里所发挥的功能。” 乔治敦伦巴狄综合癌症中心肿瘤学和儿科学学院的教授杰弗里·托雷茨基(Jeffrey Toretsky)这样说道。

In this work, scientists propose a generic model that found that aberrant IP3 receptor-mediated calcium signaling caused by type 2 transglutaminase leads to cellular dysfunction followed by brain dysfunction. Activation of transglutaminase 2, which is usually associated with inflammation and stress, and transglutaminase 2 action on the IP3 channel, may provide evidence of the common occurrence and progression of various neurodegenerative diseases.
Katsuhiko Mikoshiba, leader of the study, said: "We think the mechanism we identified in this study can provide us with a generic model for studying other diseases of the brain and other parts of the body, of which type 2 transglutaminase Amidase is up-regulated, and we hope this perception could ultimay lead to the development of new drug regimens for many neurodegenerative diseases that put a heavy burden on patients and society. "
About 50 years ago, electron microscopy revealed similar spots in the cell structure, they move around and disappear. But scientists do not know the meaning of their existence - these moving cloud-like protein collections are said to be vital to cell life and therefore they may or may provide new ways of treating the disease.
In a study published in the journal Cell Biology, two researchers called for researchers of diverse backgrounds, from biology to cell biology, to focus on the uses of these constructs, enabling a unified The term "aggregate" refers to them.
"I want to know what these assemblies in Ewing's sarcoma are doing, and Ewing's sarcoma is a disease I'm focusing on, and I think all other researchers working on human biology should also want to know how the aggregates are found in healthy people and diseases People, "said Jeffrey Toretsky, a professor at the Oncology and Paediatrics School at the Georgetown Comprehensive Cancer Center in Georgetown.