斑点热立克次体IgG ELISA检测试剂盒

Spotted fever group IgG ELISA Kit

广州健仑生物科技有限公司

主要用途：用于检测人血清中的斑点热立克次体IgG抗体

产品规格：96T/盒

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斑点热立克次体IgG ELISA检测试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
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研究人员构建了脂肪细胞缺乏ALK7，但是其他细胞都能够正常产生ALK7的小鼠。研究人员发现，缺乏ALK7受体的脂肪细胞对肾上腺素和去甲肾上腺素信号更加敏感，这一发现解释了，为何这些小鼠积累的脂肪更少，即使这些小鼠被喂食高脂肪饮食。肾上腺素和去甲肾上腺素是新陈代谢的关键因子。这些激素引发能量爆发，并加快心脏速率以及血压升高，这些都是对“战或逃”激素的必需应答。
这些激素通常刺激脂肪的分解，但是当营养物质很丰富时，脂肪细胞就会对这个信号产生抗性，从而储存脂肪。这一机制在食物供应丰富时转变为有利于能量储存，从而提高饥饿时的生存率。在工业化国家，食物经常供应不断，这种阻力可能会导致体内脂肪不健康的增加，进而导致肥胖症。
然后，研究人员研究了，阻止ALK7是否能够防止肥胖。目前，还没有已知的ALK7抑制剂，但研究人员利用小鼠生成ALK7的一个特殊突变体，使得它通过化学物质来抑制敏感，从而解决了上述的问题。这有可能实现作者能够在任何时间阻断其它正常成年动物的受体。
“使用这种方法，我们可以通过化学物质的简单调控，使得高脂肪饮食小鼠变瘦。这表明，ALK7受体的急性抑制可预防成年动物的肥胖，”神经科学系和这项研究的*作者 Tingqing Guo说。
研究人员还发现，ALK7受体在人类的脂肪细胞中的工作方式与小鼠类似。
“总的来说，这些结果表明，ALK7受体阻滞剂可能代表了一种防止人类肥胖的策略，” 神经科学系和这项研究的主要作者卡洛斯·伊瓦涅斯说。
细胞突破正常组织界限进入其他组织和器官，这是许多正常生理过程的重要一步，包括胚胎发育、伤口复原和新血管的形成。但是有时这个过程会出错。例如在转移性癌症中，指的是癌细胞从它们的源头那里开始无限扩散，并在身体的其他部位形成肿瘤。
杜克大学的生物学副教授大卫·舍伍德的一个团队采用1毫米长的秀丽隐杆线虫(C. elegans.)，研究正常发育及癌症中的调控细胞侵袭的分子机制。

The researchers constructed mice that lacked ALK7 in their fat cells, but all other cells were able to produce ALK7 normally. The researchers found that adipocytes lacking the ALK7 receptor are more sensitive to epinephrine and norepinephrine signaling, a finding that explains why these mice accumulate less fat, even though these mice are fed a high-fat diet. Epinephrine and norepinephrine are the key metabolic factors. These hormones trigger an energy burst and speed up the heart rate and blood pressure, which are all necessary responses to "war or escape" hormones.
These hormones usually stimulate the breakdown of fat, but when the nutrients are plentiful, fat cells resist the signal and store fat. This mechanism transforms into beneficial energy storage when food supplies are abundant, thereby increasing survival rates in the event of hunger. In industrialized countries, where food is regularly supplied, this resistance can lead to an unhealthy increase in body fat which can lead to obesity.
Then, the researchers studied whether preventing ALK7 could prevent obesity. There are no known inhibitors of ALK7, but researchers have used mice to generate a special mutant of ALK7 that makes it immune to chemicals by chemicals that solve the problem. This makes it possible for the author to block the receptors of other normal adult animals at any time.
"By using this method, we can make mice with high-fat diet thin by simple chemical regulation, suggesting that acute inhibition of ALK7 receptors may prevent obesity in adult animals," the Department of Neuroscience and the One author, Tingqing Guo said.
The researchers also found that ALK7 receptors work similarly in mice as fat cells in humans.
"Overall, these results suggest that ALK7 blockers may represent a strategy to prevent human obesity," said Carlos Ibanez, lead author of the Department of Neuroscience and the study.
Cells that break through normal tissue boundaries into other tissues and organs are a significant step in many normal physiological processes, including embryonic development, wound healing and neovascularization. But sometimes this process goes wrong. In metastatic cancers, for example, cancer cells start to proliferate infiniy from their source and form tumors in other parts of the body.
A team led by David Sherwood, an associate professor of biology at Duke University, used the 1-millimeter C. elegans to study the molecular mechanisms that regulate cell invasion in normal development and cancer.