果氏巴贝西虫IgM免疫荧光试剂盒

Babesia microti IgM IFA Kit

广州健仑生物科技有限公司

主要用途：用于检测人血清中的果氏巴贝西虫IgM抗体

产品规格：12 孔/张,10 张/盒

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果氏巴贝西虫IgM免疫荧光试剂盒

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

美国斯坦福大学医学院的科研人员发现，这种称为Myc的蛋白质通过一种称为微RNA的微小的调控分子起作用，抑制这些基因的表达。这标志着Myc控制的基因的一个子集*被发现是这种蛋白质的致癌功能的关键参与者，并且提示了对于Myc依赖型癌症的新的治疗靶标。
“这是思考微RNA以及染色质包装在癌症中的作用的一种不同的方式，”这项研究的资深作者、医学博士、理学博士、肿瘤学与病理学教授Dean Felsher说。“我们非常吃惊地发现一种微RNA的过度表达可能模仿Myc的致癌效应。”*作者是该校教师、医学博士、理学博士Yulin Li。
这组科研人员识别出的这些基因制造蛋白质从而管理细胞通过分裂进行自我更新、进入一种称为衰老的休息状态，或者通过细胞程序化抗原抗体永远退役。这些过程的精细控制对于控制或清除可能危险的肿瘤细胞是必要的。
为Myc蛋白编码的基因是有名的强致癌基因——致癌基因是用于描述突变或不正常表达的时候会导致癌症的基因的一个术语。它调控着一个细胞的大约1万个基因和微RNA的表达。科学家长久以来知道，让Myc失去活性或者阻断它的表达，能够导致依赖Myc的癌细胞停止生长或死亡，还会导致患Myc依赖型实体癌的小鼠的肿瘤消退。这种依赖现象称为癌基因成瘾。
微RNA是小型的RNA分子(只有大约22个核苷酸)，它和Myc一样，可以调控基因表达。此前的研究已经证明了Myc过度表达导致了称为miR-17-92的一族微RNA的水平增加。
“多年来人们已经知道myc调控着微RNA的表达，” Felsher说。“但是不清楚这与Myc的致癌功能的关系是怎样的。”

Researchers at the Stanford University School of Medicine in the United States found that this protein, known as Myc, acts through tiny regulatory molecules called microRNAs that suppress the expression of these genes. This marks the first time that a subset of Myc-controlled genes has been found to be a key player in the oncogenic function of this protein and suggests new therapeutic targets for Myc-dependent cancers.
"This is a different way of thinking about the role of microRNAs and chromatin packaging in cancer," said Dean Felsher, a senior author of the study, MD, PhD, professor of oncology and pathology. "We were very surprised to find that overexpression of a microRNA might mimic Myc's oncogenic effect." The lead author was Yulin Li, MD, Ph.D., the school's teacher.
The genes identified by the group of researchers make proteins that governs cell self-renewal by cleavage, into a state of rest called aging, or permanent retiring by a programmed antigen-antibody. Fine control of these processes is necessary to control or eliminate potentially dangerous tumor cells.
The gene that codes for Myc protein is a well-known strong oncogene - an oncogene is a term used to describe a gene that causes cancer when mutated or abnormally expressed. It regulates the expression of about 10,000 genes and microRNAs in a cell. Scientists have long known that inactivating Myc or blocking its expression can cause Myc-dependent cancer cells to stop growing or die, as well as tumor regression in mice with Myc-dependent solid cancers. This phenomenon of dependence is called oncogene addiction.
MicroRNAs are small RNA molecules (only about 22 nucleotides in length) that, like Myc, regulate gene expression. Previous studies have demonstrated that Myc overexpression leads to increased levels of a family of microRNAs called miR-17-92.
"It has been known for years that myc regulates microRNA expression," Felsher said. "But it is unclear what the relationship is with Myc's oncogenic function."