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广州健仑生物科技有限公司

主要用途：用于检测牛血清中的牛双芽巴贝西虫IgG/IgM抗体

产品规格：12 孔/张,10 张/盒

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我司还提供其它进口或国产试剂盒：登革热、疟疾、西尼罗河、立克次体、无形体、蜱虫、恙虫、利什曼原虫、RK39、汉坦病毒、深林脑炎、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

自噬作用主要发挥为细胞清除损伤和毒性蛋白的作用。那些并没有罹患Ⅱ型糖尿病的机体，自噬作用可以预防IAPP毒性蛋白的累积;而罹患Ⅱ型糖尿病的病患，这一过程没有正常工作，反而发挥破坏β细胞的作用。而β细胞分泌的胰岛素在维持血糖健康方面起重要作用。此前已有少量研究揭示过自噬作用对于β细胞功能的发挥和存活相当重要，但是并没有揭示这一过程对于导致Ⅱ型糖尿病的淀粉样蛋白的调节作用。
此次研究利用三个实验模型，分别是胰腺β细胞，表达人类IAPP的小鼠中分离出的胰岛细胞，人类胰岛。研究发现，自噬作用从胰腺β细胞清除IAPP过程中发挥重要作用。为了证实这一发现，研究人员构建了一个新型小鼠模型，该小鼠β细胞的自噬作用缺失，且还能表达人类胰岛淀粉样多肽。研究人员发现该小鼠毒性蛋白IAPP水平升高，这导致了β细胞的死亡。结果，这些小鼠进一步发展成糖尿病。除以上研究发现，此次研究再次证实Ⅱ型糖尿病和阿尔茨海默病，以及其他因毒性淀粉样蛋白的累积为标志的神经退行性疾病之间存在类似性。自噬作用同样在这些疾病过程中发挥重要作用。
此次研究旨在研究β细胞受损的细胞机制，以便确定β细胞保护的抗原抗体靶点。此次发现有助于开发新一代治疗Ⅱ型糖尿病方法。
近日，有名杂志《自然—结构和分子生物学》(Nature Structural & molecular biology) 在线刊登了中国科学院生物物理研究所秦燕研究员的科研成果“A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases，”，文章中，研究者报道了核糖体招募翻译因子的重要分子机理。
核糖体是蛋白质翻译工厂，信使RNA上携带的遗传信息在这里被翻译成蛋白质。完成蛋白质的生物合成过程需要核糖体和众多翻译因子协调完成，核糖体招募翻译因子的过程错综复杂，一直以来没有定论。

The main role of autophagy for cell damage and toxic protein damage role. Autophagy can prevent the accumulation of IAPP toxic proteins in those with no type 2 diabetes. In patients with type 2 diabetes, this process does not work properly and instead destroys beta cells. The insulin secreted by beta cells plays an important role in maintaining glycemic health. A few studies have previously revealed that autophagy is important for the function and survival of beta cells but does not reveal the regulatory effect of this process on amyloidosis leading to type 2 diabetes.
The study utilized three experimental models, pancreatic islet cells, islet cells isolated from mice expressing human IAPP, and human islets. The study found that autophagy plays an important role in the clearance of IAPP from pancreatic β cells. To confirm this finding, the researchers constructed a novel mouse model that lacked autophagy in the mouse β-cell and also expressed human amylin. The researchers found that the mice increased the level of IAPP, a toxic protein, which led to the death of beta cells. As a result, these mice further developed into diabetes. In addition to the above findings, this study again confirms the similarities between type 2 diabetes and Alzheimer's disease, as well as other neurodegenerative diseases that are marked by the accumulation of toxic amyloid. Autophagy also plays an important role in these diseases.
The aim of this study was to investigate the cellular mechanisms of beta-cell damage in order to determine the target of the beta-cell-protected antigen-antibody. The discovery helps to develop a new generation of treatments for type 2 diabetes.
Recently, the world-renowned journal Nature Structural & Molecular Biology published the latest research results of Qin Yan, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, "A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases, "the article reports on the important molecular mechanisms by which ribosomes recruit translation factors.
Ribosomes are protein translation factories where the genetic information carried on the messenger RNA is translated into protein. Completion of the protein biosynthesis process requires the coordination of ribosomes and a large number of translation factors, the process of ribosome recruitment of translation factors is complex and has not been conclusive.