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Canine Distemper IgG IFA Substrate slide

广州健仑生物科技有限公司

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
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为了验证他们的理论，该研究组使用携带破伤风毒素的病毒禁止星形胶质细胞选择性释放化学物质的能力，有效地消除了细胞与邻近细胞的沟通能力。神经细胞不受毒素的影响。
添加化学物质引发动物大脑的伽马波后，研究人员发现，携带有缺陷的星形胶质细胞的脑组织比含有健康细胞的组织产生更短的伽马波。而且，添加三个允许研究人员有选择地打开和关闭星形胶质细胞的破伤风毒素的基因后，他们发现，星形胶质细胞的信号传导被阻断的小鼠的伽玛波被削弱了。关闭毒素则抗原抗体了这一效果。
星形胶质细胞经过修改后的小鼠看似*健康的。但经过几个认知测试后，研究人员发现，它们缺乏一个主要领域：新物体识别。正如预期的那样，健康小鼠比熟悉的物品花更多的时间在置放于其环境中的新物品。与此相反，该研究组的新突变小鼠处理所有的物品的时间都是相同的。
“在某种意义上说，这原来是个惊人的结果，新物体识别记忆不只是受损，而是已经没了，就好像我们删除这一种形式的记忆，而其它完好无损，” Sejnowski说。
这个结果令人大吃一惊，部分原因是星形胶质细胞在数秒钟或更长的时间内运行，而神经元的信号却远远比这个快多了，它们是毫秒级别的。正因为如此慢的速度，因此没有人怀疑星形胶质细胞参与了需要迅速做出决定的高速大脑活动。
“传统上认为星形胶质细胞只是神经元和其他细胞的保护者和支持者，而现在发现它们也都参与了信息的处理和其他认知行为，我觉得这个观点很*，” 遗传学实验室和美国癌症协会的维尔马教授说。
这并不是说星形胶质细胞变快了——它们仍然比神经元慢多了。但新的证据表明，星形胶质细胞都在积极地为伽马波发生提供合适的环境，这反过来又使大脑更容易学习和改变神经元连接的强度。

To validate their theory, the team used tetanus toxin-containing viruses to block the ability of astrocytes to selectively release chemicals, effectively eliminating the cells' ability to communicate with neighboring cells. Nerve cells are not affected by toxins.
After chemicals added to trigger the brain's gamma waves, the researchers found that brain tissue carrying defective astrocytes produced shorter gamma waves than tissues containing healthy cells. Moreover, after adding three genes that allow researchers to selectively open and close astrocytes in the tetanus toxins, they found that the gamma waves in mice blocked by astrocyte signaling were impaired It's Anti-toxin turned off this effect.
The modified astrocytes seem compley healthy. But after a few cognitive tests, the researchers found that they lacked one of the main areas: new object recognition. As expected, healthy mice spend more time placing new items in their environment than familiar items. In contrast, the new mutant mice in the study group treated all the items for the same amount of time.
"It turned out to be a surprising result in a sense that the new object recognition memory is not just damaged, but gone, just as if we deleted this form of memory while the rest were intact," Sejnowski said.
This result is astonishing, in part because astrocytes run in seconds or more, and neurons signal much faster than this, and are millisecond-scale. Because of this slow pace, no one suspects that astrocytes are involved in high-speed brain activity that requires quick decisions.
"Traditionally, astrocytes are considered the guardians and supporters of neurons and other cells and are now found to be involved in the processing of information and other cognitive behaviors, which I find very unique," said Genetics Room and Professor Wilmer of the American Cancer Society said.
This is not to say that astrocytes become faster - they are still much slower than neurons. But new evidence suggests that astrocytes are actively providing the right environment for gamma waves to occur, which in turn makes it easier for the brain to learn and change the strength of neuronal connections.