免疫捕获军团菌检测试剂盒

广州健仑生物科技有限公司

主要用途：用于检测尿样中嗜肺军团菌血清型1抗原，以支持军团菌感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

免疫捕获军团菌检测试剂盒

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【产品介绍】

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

尽管，科学家们强调研究的抗原抗体癌和肺癌样本的数量很小，在每种情况下间质HSF1激活与患者不良预后之间的强关联确保了开展更深入的临床调查。他们补充说，一种基于HSF1的生物标记物有可能帮助预测出哪些患者的肿瘤，尤其是早期的肺癌zui有可能发展，并有可能从更积极的治疗中获益。相反，这样的信息还可以防止罹患不太具有侵袭性癌症的患者经受高毒性的治疗方法“过度治疗”所导致的副作用。
长久以来，人们认为，DNA突变不但是癌症，而且也是生物体进化改变的燃料，被认为是整个基因组随机发生的罕见事件。
然而，zui近的研究表明，癌症发展经常涉及同时产生且彼此靠近的多个突变的形成。这些基团簇突变经常被发现于染色体重排发生区域。
相关文章发表于《Cell Reports》杂志上，可能有一天会导致新的癌症疗法。根据爱荷华大学的一个生物学家和她的同事们，以及由环境卫生科学研究所的高级助理研究员Dmitry Gordenin所的一个研究组的研究表明。
基团簇突变的形成可能是由于DNA修复的过程。
自由艺术与科学的UI学院的生物学副教授Anna Malkova指出，DNA修复途径，被称为断裂诱导复制(BIR)，可以促进DNA团的突变。
“以前，我们已经表明，双链DNA断裂(这可以产生氧化，电离辐射和复制错误)，可以通过BIR修复，” Malkova说。
“在BIR期间，断裂DNA的末端与另一个染色体上的相同的DNA序列配对，并启动一个不同寻常类型的复制，和迁移泡沫一样的行进，并与大量的单链DNA的积累有关，” 她说。
在本研究中，研究人员研究了遭受到烷化剂(细胞的杀伤剂)伤害的酵母细胞的BIR过程。“我们发现，BIR过程中的单链DNA积累容易受到导致基团簇突变形成的伤害，”文章的另一*作者、 UI博士后 Cynthia Sakofsky解释道，“这些基团簇与在人类癌症中发现的相似。”

Although scientists underscore the small number of antigen-antibody and lung cancer samples studied, the strong association between interstitial HSF1 activation and poor prognosis in each patient led to a deeper clinical investigation. They add that a HSF1-based biomarker may help predict which patients' tumors, especially early-stage lung cancer, are most likely to develop and may benefit from more aggressive treatment. Conversely, such information can also prevent side effects caused by "over-treatment" of patients with less aggressive cancers undergoing hyper-toxic treatments.
It has long been believed that DNA mutations are not only cancers, but also fuels of evolutionary changes in organisms, and are thought to be a rare event in which the entire genome is randomly generated.
However, recent studies show that cancer development often involves the formation of multiple mutations that are produced simultaneously and close to each other. These cluster mutations are often found in chromosomal rearrangements.
Related articles in the Cell Reports magazine may one day lead to new cancer therapies. According to a study by a biologist and her colleague at the University of Iowa and a research team led by Dmitry Gordenin, senior assistant researcher at the Institute of Environmental Health Sciences.
The formation of cluster mutations may be due to the process of DNA repair.
Anna Malkova, associate professor of biology at the Free Academy of Arts and Sciences's UI Institute, points out that the DNA repair pathway, known as fracture-inducible replication (BIR), promotes mutations in DNA clusters.
"In the past, we have shown that double-stranded DNA breaks (which can produce oxidation, ionizing radiation and replication errors) that can be repaired by BIR," Malkova said.
"During BIR, the ends of the cleaved DNA pair with the same DNA sequence on another chromosome and initiate an unusual type of replication that travels like a migrating foam and is associated with the accumulation of large quantities of single-stranded DNA," she said Say.
In this study, researchers studied the BIR process of yeast cells that were damaged by alkylating agents (cell killers). "We found that single-stranded DNA accumulation during BIR is vulnerable to damage caused by cluster mutations," explained Cynthia Sakofsky, UI postdoctoral fellow at the UI. "These clusters are associated with the discovery in human cancers Similar. "