EIKEN嗜肺军团菌试剂盒（免疫捕获法）

广州健仑生物科技有限公司

主要用途：用于检测尿样中嗜肺军团菌血清型1抗原，以支持军团菌感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

EIKEN嗜肺军团菌试剂盒（免疫捕获法）

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【产品介绍】

EIKEN

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

在医学系博士后研究人员Gopinath Sutendra和Evangelos Michelakis教授的下，这一研究小组发现过去被认为仅定位在线粒体内的一种酶: 丙酮酸脱氢酶复合体(PDC)实际上可以进入到细胞核中，完成它在线粒体中所做的事情：生成乙酰辅酶A。在线粒体中时，PDC利用我们饮食中的碳水化合物来生成乙酰辅酶A是为了产生能量。而在细胞核中，PDC生成乙酰辅酶A是为了实现组蛋白乙酰化。
Sutendra说：“一种酶从一个细胞器跳跃到另一个细胞器中，这真是*，我们的结果相当的惊人。我们原本想检测线粒体中乙酰辅酶A的水平和PDC,因为我们认为它们存在于那里。然而偶然地我们同时得到了分离出的细胞核，我们在细胞核中看到了PDC。因此我们提出了疑问，‘PDC在那里做什么?’一切由此开始。”
Michelakis 说：“我们惊讶地发现，尽管早就认识到了组蛋白乙酰化在细胞生物学和医学中的重要性，尽管许多人付诸了努力来开发调控组蛋白乙酰化的药物，但对于细胞核中乙酰辅酶A的来源仍不清楚。有时候一些重要的生物学问题的答案就在我们身边，等待着我们去发现。”
该研究小组发现PDC易位到细胞核中使得癌细胞以更快的速度生长，这一发现或许可促成抗癌战争其他的一些策略。由于这些研究结果与一般情况下我们的DNA调控有关，这项研究有可能对于表观遗传调控起至关重要作用的、许多生理和病理情况产生更广泛的影响。“发现将能量生成(新陈代谢过程)与基因调控在一起的这一新信号通路，我们感到非常的兴奋，”研究人员说。
根据science上一篇文章介绍，一种细胞应激通路称为未折叠蛋白反应(UPR)既可以激活也可以降低死亡受体5蛋白(DR5)，它能促进或预防细胞抗原抗体。该理论认为初始应激阻止细胞抗原抗体或凋亡，以使细胞有机会去适应，但是如果应激持续下去，它zui终触发凋亡。
普林斯顿大学分子生物学教授Alexei Korennykh说“这项研究使得所有这种大的复杂的烂摊子的zui美丽简化。基本上，他们识别和精确定位与这一开关决定有关的特殊蛋白并解释这一决定是怎么做的。”但是加利福尼亚拉霍亚伯纳姆医学研究所的Randal Kaufman 并没有留下深刻印象。他怀疑支持作者主要理论关于这一关键细胞过程的实验生理学关联性。

Led by Gopinath Sutendra and Evangelos Michelakis, postdoctoral researchers in the Department of Medicine, the team found that the enzyme, pyruvate dehydrogenase complex (PDC), an enzyme previously thought to locate only within the mitochondria, can actually enter the nucleus , To accomplish what it does in the mitochondria: generate acetyl-CoA. In mitochondria, PDC uses the carbohydrates in our diet to produce acetyl-CoA for energy production. In the nucleus, PDC produces acetyl-CoA for histone acetylation.
Sutendra said: "It's really unheard of that an enzyme jumps from one organelle to another organelle, and we're pretty alarming.We originally wanted to examine acetylcholine-coenzyme A levels and PDC in the mitochondria because we thought they were there. Occasionally, however, we got both separated nuclei, and we saw the PDC in the nucleus, so we asked the question, 'Where does the PDC do?'
"We were surprised to find that although the importance of histone acetylation in cell biology and medicine has long been recognized, and despite the many efforts that have been made to develop drugs that regulate histone acetylation, in the nucleus The source of acetyl-CoA remains unclear, and sometimes the answers to some of the key biological questions are right around us, waiting for us to discover. "
The team's discovery that PDC translocates to the nucleus to allow cancer cells to grow at a faster rate may have led to other strategies to fight cancer. Since these findings are linked to our DNA regulation in general, this study is likely to have a broader impact on many physiological and pathological conditions, which are crucial for epigenetic regulation. "We are excited to find this new signal pathway linking energy production (metabolic processes) to gene regulation," the researchers said.
According to an article in science, a cellular stress pathway called unfolded protein response (UPR) activates or reduces the death receptor 5 protein (DR5), which promotes or prevents cellular antigen antibodies. The theory holds that initial stress prevents cellular antigen antibodies or apoptosis, so that cells have a chance to adapt, but it eventually triggers apoptosis if stress persists.
Alexei Korennykh, a professor of molecular biology at Princeton University, said: "This study makes the most beautiful simplification of all this big, complex mess, and basically they identify and pinpoint specific proteins that are relevant to this switch decision and explain that What to do. "But Randal Kaufman of La Jolla Burnham Medical Institute in California did not impress. He doubted his support for the author's primary theory of the experimental physiology of this crucial cellular process.