百日咳IgG抗体定量酶联免疫法检测试剂盒

英文名称：Bordela Pertussis IgG (quant.)

广州健仑生物科技有限公司

（广州健仑生物科技有限公司是集研制开发、销售、服务于一体的优良企业,公司产品涉及临床快速诊断试剂、食品安全检测试剂，违禁品快速检测，动物疾病防疫检测试剂，免疫诊断试剂、临床血液学和体液学检验试剂、微生物检验试剂、分子生物学检验试剂、临床生化试剂、有机试剂等众多领域，同时核心代理Panbio、FOCUS、Qiagen、IBL、CORTEZ、Fuller、Inbios、BinaxNOW、LumuQuick、日本富士、日本生研等多家有名诊断产品集团公司产品，致力于为商检单位、疾病预防控制中心、海关出入境检疫局、卫生防疫单位,缉毒系统，戒毒中心，检验检疫单位、生化企业、科研院所、医疗机构等机构与行业提供*、高品质的产品服务。此外，本公司还开展食品、卫生、环境、药品等多方面的第三方检测服务。）

主要用途：用于定量测定人血清、脑脊液或血浆中的百日咳抗体。

产品规格：96T/盒

存储条件：4-8℃

保质期：18个月

【产品介绍】

Pertussis IgG Antibody Quantification Kit (Enzyme-Linked Immunosorbent Assay) For the quantitative detection of anti-pertussis antibodies in human serum and plasma. The reagent can be used for the diagnosis and epidemiological study of acute or recent pertussis infection, while IgG-ELISA reagent is used to monitor the vaccination.

Bordela pertussis belongs to the genus Bordela and is a small globular Gram-negative bacillus. Bordela pertussis is the causative agent of pertussis, a global infectious disease that spreads from person to person through droplets. Babies 0-4 years old are particularly vulnerable to infection. Infants and toddlers have a very high mortality rate High (Infant mortality rate within 1 year old is 60%) 1.

Bordela pertussis is attached to the mucosal ciliated cells of the respiratory tract through its surface ligands. One of the important adhesion proteins is also an important immunogen (antigen), known as Filamentous HemAgglutinin (hereinafter referred to as "FHA"). The synergistic effect of several virulence factors will promote the colonization of bacteria in the respiratory tract and trigger infection.

Bordela pertussis synthesizes and secretes a specific toxin known as Pertussis Toxin (PT), an important virulence factor. Pertussis toxin can produce complex biological effects, such as leukocytosis, lymphocytosis and the body's sensitivity to histamine increased.

A typical pertussis in three stages, after 1-2 weeks of incubation, enters the period of mucosal inflammation (highly contagious), which lasts 1-2 weeks, with a noncharacteristic cough , Rhinitis, and conjunctivitis; the next is the spasm (paroxysmal cough), paroxysmal cough often accompanied by vomiting mucus, laryngospasm and bronchospasm, resulting in infantile bruising, then repeated, sharp Of breath, then continue to cough, severe cases of seizures up to 50 times a day; 4-6 weeks later, the frequency of disease attacks will be reduced and gradually calm down (remission, the duration of up to 6 months).

Infected patients usually produce IgM-, IgA- and IgG-antibodies at the second week of the spasticity (see Figure 1), IgM-antibodies last 2-3 months, and IgA-antibodies rise from the spasm Start for 4-6 months.

IgG-antibodies peak at 6-8 weeks and are detectable until adulthood; IgM- and IgG-antibodies are produced immediay after vaccination; for infants and young children up to 6 months, specific IgM- Antibodies are suitable for the early diagnosis of recent infections, whereas specific IgA-antibodies show better diagnostic properties in infants and young children over 6 months; infants within 3 months do not produce IgA-antibodies.

【检测原理】

用抗原包被微量板孔，制成固相载体。加患者血清到板孔中，其所含的抗体特异性地与固相载体中现存抗原结合，形成免疫复合物。除去多余物质后，加入结合了碱性磷酸酶的IgG、IgA或IgM抗体，使之与上述免疫复合物反应。洗板，除去多余的结合物，加入底物（对硝基苯磷酸盐）。其与酶结合的免疫复合物反应，产生有颜色产物，颜色强度与特异性抗体含量成正比。

百日咳IgG抗体定量酶联免疫法检测试剂盒

【试剂盒的组成】

ELISA classic百日咳 IgG: 

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