日本生研甲乙型流感快检试剂盒

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日本生研甲乙型流感快检试剂盒

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

“随着其它基因变化一起，失活的Pax5驱动正常血细胞变成白血病细胞，之前已经报道过，”刘女士说。“然而我们*揭示重新复活Pax5能够使细胞重新开始其正常发育并丢失那些类似癌症的特性，有效地治疗白血病。吸引我们的是只是回复Pax5就足够使这些癌细胞恢复常态化，尽管其它基因是改变的。”
白血病中，未成熟白血细胞复制异常并在骨髓中累积，干扰正常血细胞的产生。
刘女士说在儿童B-ALL中Pax5常常是一个‘消失’的基因。“Pax5对于一种白血细胞——b细胞正常发育*的，”她说。“当Pax5功能缺乏抵抗力时，发育中的B细胞陷入一种不成熟状态并且变成癌性的。我们证明恢复Pax5功能，即使是在已经发生癌病的细胞中，移除这个‘阻塞’，使得细胞发育成正常白血细胞。”
Dickins博士说这项研究揭示了Pax5的功能，是约100种已知‘抑制’人类肿瘤的基因之一。“当这些肿瘤抑制基因通过改变DNA而被失活时，肿瘤开始发育，”Dickins博士说。
“这项工作揭示如何钝化肿瘤抑制基因Pax5促成B-ALL 发育以及白血病细胞如何变成‘热爱’低Pax5水平以继续激增。纵使B-ALL 细胞有多种基因突变，只是简单的复活Pax5引起肿瘤细胞恢复正常发育并失去它们的癌变性质。”

"As other genetic changes, inactivated Pax5 drives normal blood cells to become leukemic cells, as previously reported," Ms. Liu said. "However, for the first time, we have shown that resuscitation of Pax5 allows cells to restart their normal development and lose those cancers-like properties that effectively treat leukemias, and it is enough to appeal to Pax5 that these cells are restored to normalization, although other genes are changed."
In leukemia, immature white blood cells replicate abnormally and accumulate in the bone marrow, interfering with the production of normal blood cells.
Ms. Liu said Pax5 is often a 'vanishing' gene in children with B-ALL. "Pax5 is essential for the normal development of a white blood cell-b cell," she said. "When Pax5 function lacks resistance, developing B cells plunge into an immature state and become cancerous.We show that restoring Pax5 function, even in cells where cancer has already occurred, removes this 'obstruction' , Making the cells develop into normal white blood cells. "
Dr. Dickins said the study revealed the function of Pax5 and is one of about 100 genes known to 'suppress' human tumors. "Tumors begin to develop when these tumor suppressor genes are inactivated by changing DNA," says Dr. Dickins.
"This work revealed how to passivate the tumor suppressor gene Pax5 to promote B-ALL development and how leukemic cells turn into 'loving' low Pax5 levels to continue the surge even though B-ALL cells have multiple genetic mutations that simply cause Pax5 to resuscitate Tumor cells resume normal development and lose their cancerous properties. "