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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

*步是要证实在感染MCMV的小鼠中，NK细胞的确产生IL-10。研究人员注意到，在高度感染的小鼠中，NK细胞在被感染约3.5天后产生IL-10，3.5天过后，他们会产生IFN-γ，这种蛋白质有助于增强免疫应答，而不是化解。
在实验室培养中，他们发现，只有那些约3.5天后感染的细胞会产生IL-10。随后的实验表明，本质上，暴露于病毒是没有必要的，而是几轮复制和增殖(约3天)能够产生IL-10。
“总而言之，这些研究表明，无论是在体外条件下独立的感染下，还是在体内感染过程中，N??K??细胞的广泛增殖与IL-10产生有关，”作者说。
已经表明，IL-10的产生是与NK细胞的增殖有关，Tarrio，比隆和同事寻求更多的证据：触发开关产生IL-10的NK细胞的机制。
他们在感染的小鼠中，对NK细胞增殖前和后的全基因组的构象进行比较。他们发现，NK细胞尚未发生增殖过程时，IL-10基因被紧紧地包裹起来，而无法进行表达。细胞进行增殖时的IL-10基因被打开使其更容易表达。
“当我们得到这些结果时，大家都非常兴奋，因为在体内的感染过程中，从一个细胞群中挖掘表观遗传改变是相当不俗的，” Tarrio说。

The first step was to confirm that NK cells did produce IL-10 in mice infected with MCMV. The researchers noted that NK cells produce IL-10 after about 3.5 days of infection in highly infected mice, and after 3.5 days, they produce IFN-γ, a protein that helps boost the immune response rather than defuse .
In laboratory culture, they found that only those cells infected about 3.5 days later produced IL-10. Subsequent experiments showed that, essentially, exposure to the virus is not necessary, but several rounds of replication and proliferation (about 3 days) are capable of producing IL-10.
"All in all, these studies show that the extensive proliferation of N? K cells is associated with IL-10 production both independently of in vitro conditions and during in vivo infection," the authors said.
It has been shown that the production of IL-10 is related to the proliferation of NK cells, and Tarrio Billund and colleagues seek more evidence of the mechanism that triggers the switch to produce IL-10-producing NK cells.
They compared the genome-wide conformation of NK cells before and after their proliferation in infected mice. They found that when NK cells have not yet proliferated, the IL-10 gene is tightly packed and can not be expressed. When the cells proliferate, the IL-10 gene is opened to make it easier to express.
"When we got these results, everyone was very excited, because in the body of the infection, mining epigenetic changes from a cell population is quite impressive," Tarrio said.