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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

“垃圾从神经元转移到神经胶质细胞的标准流程的发现，zui有可能是理解大脑和神经退行性或代谢紊乱的与年龄相关的衰退功能的关键，” Marsh-Armstrong说。“我们希望在生物医学的其他领域上也有一样重要的影响。”
研究人员仔细地观察小鼠的视网膜神经节细胞的轴突，这一种类型的神经元从眼睛传送视觉信息到大脑。结合*显微镜和Ellisman和Marsh-Armstrong实验室开发的分子生物技术，他们发现，视网膜神经节细胞的受损线粒体脱落在ONH中。这些线粒体由相邻的星形胶质细胞吸收和降解。
这项研究抗原抗体了传统的观点，即细胞内部分离，降解和去除损坏的细胞器，这个过程通常被称为自噬(希腊语为“自吃”)。当这个过程涉及线粒体时，它被称为线粒体自噬。Marsh-Armstrong， Ellisman和其同事们所描述的这个过程被命名为“transmitophagy”。
Ellisman说，这一发现可能提高对各种疾病的认识，zui终也许为各种疾病的治疗提供线索。“线粒体在轴突的健康中有着显著的作用。优*一步探索transmitophagy发生了什么，以及这一现象的缺陷是否导致神经元功能障碍或疾病。”

"The discovery of the standard flow of trash from neurons to glial cells is most likely the key to understanding the age-related decline of brain and neurodegenerative or metabolic disorders," said Marsh-Armstrong. "We hope there will be equally important implications in other areas of biomedicine."
Researchers carefully examined the axons of retinal ganglion cells in mice, a type of neuron that sends visual information from the eye to the brain. Combined with advanced microscopy and molecular biology developed by Ellisman and Marsh-Armstrong Laboratories, they found that impaired mitochondrial detachment of retinal ganglion cells in ONH. These mitochondria are absorbed and degraded by adjacent astrocytes.
This study of antigen-antibody has the traditional view that the internal separation of cells, degradation and removal of damaged organelles, this process is often referred to as autophagy (Greek for "self-eating"). When this process involves mitochondria, it is called mitochondrial autophagy. The process described by Marsh-Armstrong, Ellisman and colleagues was named "transmitophagy."
Ellisman said the finding may raise awareness of various diseases and may eventually provide clues to the treatment of various diseases. "Mitochondria play a significant role in the health of axons, giving priority to further exploration of what happens to transmitophagy, and whether the flaws in this phenomenon lead to neuronal dysfunction or disease."