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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

肥胖是一个世界性的流行病，并以惊人的速率导致糖尿病和心血管疾病，但目前还缺乏有效的药物来治疗肥胖。在Cell杂志上发表的两项不相关的研究，揭示了免疫途径在活化好的类型的脂肪(被称为棕色和米色脂肪)中有重要作用，此类脂肪燃烧储存的热量，减轻体重，改善代谢健康。这一发现可能为肥胖及相关代谢性疾病的治疗铺平道路。
Dana-Farber癌症研究所和哈佛医学院Bruce Spiegelman表示：我们的想法是代谢健康可以通过激活脂肪中免疫细胞得到改善，这项研究揭示了一个令人兴奋的新一类的潜在治疗方法，可能有一天可用于肥胖症相关疾病。
人类婴儿有大量能产生热量的棕色脂肪，以?；に敲馐苎虾?，科学家zui近发现，成人体内保留少量的棕色脂肪，寒冷暴露下或运动可激活棕色或米色脂肪，燃烧储存的热量，保护哺乳动物的体温。尽管这类脂肪有用于治疗这些疾病的潜力，但相对很少有人知道有关触发这些良好类型脂肪形成的分子途径。
在新的研究中，为了解决这个问题，Dana-Farber癌症研究所和哈佛医学院Spiegelman和Rajesh Rao集中在一个叫做PGC-1alpha4的蛋白(zui近发现的蛋白，其响应抗阻练习促进肌肉生长)。他们发现，PGC-1alpha4刺激一种新发现的激素Metrnl的分泌，Metrnl被释放到血液中，并在小鼠运动后的肌肉组织和寒冷暴露后的脂肪组织中产生。

Obesity is a worldwide pandemic and causes diabetes and cardiovascular disease at an alarming rate, but there is a lack of effective drugs to treat obesity. Two unrelated studies published in the journal Cell revealed that the immune pathways play an important role in activated types of fats known as brown and beige fats, which burn stored heat, lose weight, improve Metabolic health. This finding may pave the way for the treatment of obesity and related metabolic diseases.
Bruce Spiegelman, MD, of the Dana-Farber Cancer Institute and Harvard Medical School, said: "Our idea is that metabolic health can be improved by activating immune cells in the fat. This study reveals an exciting new class of potential treatments that may have One day can be used for obesity-related diseases.
Human babies have large amounts of calorie-producing brown fat to protect them from the cold. Researchers have recently discovered that small amounts of brown fat are retained in adults, brown or beige fat is activated or exposed in cold climates, burning stored heat and protecting mammals The body temperature. Although such fats have potential for the treatment of these diseases, relatively few people know the molecular pathways involved in triggering these good types of adipogenesis.
In a new study, Dana-Farber Cancer Institute and Harvard Medical School Spiegelman and Rajesh Rao focused on a protein called PGC-1alpha4 (a recently discovered protein that responds to anti-stress exercises to promote muscle growth) in order to address this issue. They found that PGC-1alpha4 stimulates the secretion of a newly discovered hormone known as Metrnl, which is released into the blood stream and is produced in muscle tissue in mice after exercise and in fatty tissue after cold exposure.