乙型流感病毒IgA ELISA免疫诊断试剂盒

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【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

通过转换储能的白色脂肪成为燃烧卡路里的棕色或米色脂肪，Metrnl增加能量消耗，提高肥胖、糖尿病小鼠的代谢健康。这种激素，有可能适合作为肥胖和糖尿病的治疗新靶标，Metrnl是通过激活免疫分子白细胞介素-4和白细胞介素13，以及位于脂肪组织的免疫细胞即巨噬细胞发挥这些积极的效果。
发表在同一杂志上的另一项研究，进一步揭示了免疫反应和肥胖的相关问题，旧金山加州大学Ajay Chawlazui近的研究探究了在应对寒冷环境中，免疫系统激活棕色脂肪。现在Chawla和他的团队发现了小鼠体内米色脂肪活化的基本“线路”。他们发现，interleukin-4/13信号激活白色脂肪组织中的巨噬细胞，导致转换白色脂肪成为米色脂肪所需的神经系统分子的生成。这些发现揭示了重要的新见解，即免疫系统和神经系统如何协同工作来刺激米色脂肪的形成。
此外，研究人员发现，这种免疫通路信号受损的小鼠产生较少的米色脂肪，具有较低的能量消耗，并且在寒冷的环境中，与正常小鼠相比无法维持自己的体温。与此相反，用白细胞介素-4处理小鼠能增加米色脂肪的形成，降低体重，改善肥胖小鼠代谢健康。

Metrnl increases energy expenditure and improves the metabolic health of obese, diabetic mice by converting stored energy white fat to brown or beige fat that burns calories. This hormone, potentially suitable as a novel target for the treatment of obesity and diabetes, Metrnl exerts these positive effects by activating the immune molecules interleukin-4 and interleukin-13, as well as the immune cells located in adipose tissue, macrophages.
Another study, published in the same journal, further uncovered questions about the immune response and obesity. A recent study by Ajay Chawla at the University of California, San Francisco, explored the activation of brown fat by the immune system in response to cold conditions. Now Chawla and his team found the basic "line" of beige fat activation in mice. They found that interleukin-4/13 signaling activates macrophages in white adipose tissue, resulting in the production of neuronal molecules needed to convert white fats to beige fats. These findings reveal important new insights on how the immune system and the nervous system work together to stimulate the formation of beige fats.
In addition, the researchers found that mice with impaired immune signaling generated less beige fat, had lower energy expenditure, and were unable to maintain their body temperature in cold conditions compared to normal mice. In contrast, treatment of mice with interleukin-4 increased the formation of beige fat, decreased body weight, and improved the metabolic health of obese mice.