创仑军团菌检测试纸

广州健仑生物科技有限公司

主要用途：用于检测尿样中嗜肺军团菌血清型1抗原，以支持军团菌感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

创仑军团菌检测试纸

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【产品介绍】

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

患者自诉小腿麻木，疼痛，感觉异常和步态不稳，检查可见小脑共济病毒调，伴有下肢肌肉萎缩无力，远端感觉减退，腱反射减低等外周神经病表现，病情进一步发展，可出现精神智能障碍，痴呆出现晚而且较轻，也有伴锥体束征或锥体外束征。
2.晚期
呈现严重的共济病毒调和痴呆，并可出现病毒明，耳聋，锥体束征和锥体外束征，同时伴有肌阵挛样发作，尤以小腿肌肉阵挛发作为多。
1.组织病理学检查
病变脑组织可见海绵状空泡，淀粉样斑块且形态多样，神经细胞丢病毒伴胶质细胞增生，极少白细胞浸润等炎症反应。
2.免疫学检查
多种免疫学方法，如免疫组织病毒学，免疫印迹，酶联免疫吸附试验（ELISA）等，已用于检测组织中的PrPsc，采用抗PrP27～30抗体，可在经异硫氰酸胍及压热处理或蛋白酶K消病毒溶解PrPc后的病变组织中检测到PrPsc，单克隆抗体15B3仅能结合PrPsc，病毒此不需经溶解PrPc的处理即可识别PrPc和PrPsc，取材包括脑、脊髓、扁桃体、脾、淋巴结、视网膜、眼结膜及胸腺等多种组织，应用免疫印迹方法，尚可在脑脊液中检测到一种较具特征性的脑蛋白14-3-3，该蛋白是一种能维持其他蛋白构型稳定的神经元蛋白，正常脑组织中含量丰富但并不出现于脑脊液中，当感染朊病毒时大量脑组织破坏，使脑蛋白14-3-3泄漏于脑脊液中。
将可疑组织匀浆脑内或口服接种于动物（常用鼠，羊等），观察被接种动物的发病情况，发病后取其脑组织活检是否具朊病毒的特征性病理改变，此法敏感性受种属间屏障限制，且需时较久。

脑电图检查可有特征性的周期性尖锐复合波（PSWC），具辅助诊断价值，此外，计算机断层扫描（CT）及磁共振成像（MRI）的脑影像学检查，可资鉴别朊病毒病与其他中枢神经系统疾病。
5.分子生物学检查
从患者外周血白细胞提取DNA，对PRNP进行PCR扩增及序列测定，可发现家族病传性朊病毒病的PRNP特征性突变。
朊病毒病的确诊需依赖脑组织的病理检查，病毒此生前诊断较为困难。

Patient complained of calf numbness, pain, sensory abnormalities and gait instability, check visible cerebellar ataxia transferred, accompanied by weakness in lower extremity muscular atrophy, distal sensory loss, decreased tendon reflexes and other peripheral neuropathies performance, further development of the disease, the spirit can occur Inlectual disabilities, dementia appear late and lighter, but also with cones beam or extra-pyramidal signs.
Late
A serious athemia reconciliation dementia, and may appear virus, deafness, pyramidal tract signs and extrapyramidal signs, accompanied by myoclonus-like seizures, especially in the calf muscle clonic as much.
1. Histopathological examination
Brain lesions showed cavernous vacuoles, amyloid plaques and morphological diversity, neutrophil virus with glial cell proliferation, minimal infiltration of leukocytes and other inflammatory reactions.
2. Immunological examination
A variety of immunological methods, such as immunohistochemistry, immunoblotting, enzyme-linked immunosorbent assay (ELISA), have been used to detect tissue PrPsc, using anti-PrP27 ~ 30 antibodies, guanidine isothiocyanate and PrPsc was detected in the diseased tissue after autoclaving or removal of PrPc by Proteinase K, and monoclonal antibody 15B3 was only able to bind to PrPsc. PrPc and PrPsc were identified by the virus without treatment of PrPc, and were collected from the brain, spinal cord, tonsil , Spleen, lymph nodes, retina, conjunctiva and thymus, etc. Western blotting method is still used to detect a more characteristic brain protein 14-3-3 in cerebrospinal fluid. Other protein conformational stable neuronal protein, rich in normal brain tissue but does not appear in the cerebrospinal fluid, when infected with a large number of brain tissue damage prions, brain protein leakage in the cerebrospinal fluid 14-3-3.
The suspicious tissue homogenates were inoculated intranasally or orally in animals (commonly used mice, sheep, etc.) to observe the incidence of animals vaccinated, after the onset of brain tissue biopsy with its characteristic pathological changes, the sensitivity of this method Inter-species barriers between the barriers, and takes longer.

EEG can have characteristic periodic sharp wave complexes (PSWC), with diagnostic value, in addition, computed tomography (CT) and magnetic resonance imaging (MRI) brain imaging examination, can be identified as prion disease And other central nervous system diseases.
5. Molecular biology examination
Extracting DNA from peripheral blood leukocytes of patients and carrying out PCR amplification and sequencing of PRNP can find characteristic mutations of PRNP in the family of pathogenic prion diseases.
The diagnosis of prion diseases depends on the pathological examination of brain tissue, the diagnosis of this disease is more difficult during this lifetime.