CBFB(16q22)基因断裂探针

 广州健仑生物科技?有限公司 

本司长期供应尼古丁（可替宁）检测试剂盒，其主要品牌包括美国NovaBios、广州健仑、广州创仑等进口产品，国产产品，试剂盒的实验方法是胶体金方法。

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

CBFB(16q22)基因断裂探针

   本试剂盒主要用于CBFB(16q22)基因断裂的检测，里面包括即用型杂交液和DAPI复染剂。
本试剂盒仅供科研使用。

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CBFB(16q22)基因断裂探针

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 

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【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室

【企业文化宣传】CBFB(16q22)基因断裂探针

基因测序技术的出现，正在帮zhu考古学家有勇气重新打开一些尘封已久的谜团。

近日，英国科学家揭开了4000年前埃及木乃伊的一个巨大谜团：英国曼彻斯特博物馆有名的“俩兄弟”木乃伊实际上拥有不同的父亲，也就是说他们是同母异父的半兄弟。曼彻斯特大学信息显示，该校研究团队使用的是第二代DNA测序技术（又称“高通量测序”），相关成果发表在有名考古期刊《考古科学》（Journal of Archaeological Science）。

这“俩兄弟”是曼彻斯特博物馆中zui古老的木乃伊，也是埃及古物学收藏中有名的人体遗骸。他们分别是两名男性，Khnum-nakht和Nakht-ankh，历史则可追溯至公元前1800年。

基因测序揭开埃及木乃伊血缘

让这“俩兄弟”问世的是20世纪早期的埃及古物学家Flinders Petrie 和Ernest Mackay指导下的埃及工人，他们在1907年发现了这两具木乃伊，地点是在开罗以南250公里处的一个叫Deir Rifeh的村庄。

这两具木乃伊被命名为“俩兄弟”的原因则是当时被发现的时候他们是合葬在一起。棺材上的象形文字碑文提示，这两个人都是当地一位名字不详的官员的儿子，而他们的母亲则同名，都叫 Khnum-aa。也就是从那时候起，这两兄弟便以“俩兄弟”被人熟知。

然而，自1907年“俩兄弟”被发现以来，埃及古物学者中一直存在一种争议：他们是否真正相关？

实际上，就在这两具木乃伊被发现的第二年，也就是1908年，坟墓中所有的物品被运至曼彻斯特，两具木乃伊也由英国*位职业女性埃及古物学家Margaret Murray博士打开。Murra团队通过大不相同的骨骼形态学推断，两者或许并不存在家庭关系。结合当时碑文的证据，团队认为“俩兄弟”中的一位是领养的。

直到2015年，科学家从他们的牙齿中提取了“古老DNA”，以期真正揭开这一谜底，结束争议。

科学家从两具木乃伊的牙齿中提取DNA，在线粒体和Y染色体片段的杂交捕获后，通过高通量DNA测序技术进行测序。分析表明，Nakht-Ankh和Khnum-Nakht都属于线粒体单体型M1a1，这也就暗示了母体的关系。Y染色体序列虽然不完整但表明两具木乃伊之间存在差异，这暗示Nakht-Ankh和Khnum-Nakht有不同的父亲，因此很可能是半兄弟。这也是是*例成功使用线粒体和Y染色体DNA在埃及木乃伊中分型的研究。

主持这项基因测序工作的是曼彻斯特大学地球与环境科学学院Konstantina Drosou教授。Drosou表示，“这是一项漫长而又耗费精力的工作，但zui终我们获得了结果。我很欣慰我们能够为这个巨大的历史谜团新添一块很小但很重要的拼图，我确信‘俩兄弟’会为我们感到自豪，这是我们相信古代DNA的时刻。”

The emergence of gene sequencing technology is helping archaeologists to have the courage to reopen some of the long dusty mysteries.

Recently, British scientists opened 4000 years ago, Egyptian mummy a huge mystery: Manchester Museum of the famous British "brothers" Mummy actually has a different father, that is to say they are half brothers and half. University of Manchester official website information shows that the school's research team used the second generation of DNA sequencing technology (also known as "high-throughput sequencing"), and the related results were published in the international famous archaeological Journal Journal of Archaeological Science.

The "two brothers" are the oldest mummies in the Manchester Museum and the most famous human remains in the Egyptian antiquities collection. They are two men, Khnum-nakht and Nakht-ankh, and history dates back to 1800 BC.

Gene sequencing uncovers the blood of Egyptian mummies

The "two brothers" came out of Egypt in the early twentieth Century under the guidance of Flinders Petrie and Ernest Mackay. They found the two mummies in 1907, located in a village called "Deir Rifeh" 250 kilometers south of Cairo.

The two mummies were named "cause brothers" is found when they are buried together. The pictographic inscriptions on the coffin indicate that the two men are sons of a local official whose name is unknown, while their mother is called Khnum-aa. From that time, the two brothers were well known by the "two brothers".

However, since the discovery of "two brothers" in 1907, there has been a dispute among Egyptians in Egypt: are they really related?

In fact, in the second years when the two mummy was discovered, in 1908, all the articles in the tomb were transported to Manchester. The two mummy was also opened by the first British professional woman, Dr. Margaret Murray, an Egyptian archaeologist. The Murra team deduced from the different skeletal morphology that there might be no family relationships between the two. In combination with the evidence of the inscription at the time, the team believed that one of the two brothers was adopted.

Until 2015, scientists extracted the "old DNA" from their teeth to truly uncover the mystery and end the dispute.

The scientists extracted DNA from two mummified teeth, and sequenced it through high throughput DNA sequencing after the hybridization of mitochondrial and Y chromosome fragments. The analysis shows that both Nakht-Ankh and Khnum-Nakht belong to the mitochondrial haplotype M1a1, which suggests the maternal relationship. Although the Y chromosome sequence is incomplete, it indicates that there are differences between two mummies. This implies that Nakht-Ankh and Khnum-Nakht have different fathers, so they are probably half brothers. This is the first study of the successful use of mitochondrial and Y chromosome DNA in Egyptian mummies.

The gene sequencing was conducted by Professor Konstantina Drosou of the school of earth and Environmental Sciences, University of Manchester.  Drosou said, "it's a long and exhausting job, but eventually we get the result.  I'm glad we can for the history of this great mystery added a very small but very important puzzle, I believe that the "two brothers" will be proud of us, we believe that this is the ancient times DNA."